choose one of these function forms (WEIBULL was chosen for the example) #code does not apply because 0 at risk at last time point # adding times for patients at risk at last time point Times_end <-c( rep(end_time_censor, n_censors), rep(end_time_event, n_events) ) Times_start <-c( rep(start_time_censor, n_censors), rep(start_time_event, n_events) ) Setwd("insert the folder path where the data is stored") Update directory name and text file name in line below I use Stata's data library for convenience.) Open Stata and enter the following in the command line: (You can use any published Kaplan-Meier curve. We will use an example dataset from Stata’s data library. Generate a Weibull curve that closely resembles the survival function and whose parameters can be easily incorporated into a simple three-state Markov model Specifically, I will describe how to:Ĭapture the coordinates of a published Kaplan-Meier curve and export the results into a *.CSV fileĮstimate the survival function based on the coordinates from the previous step using a pre-built template This blog provides a practical, step-by-step tutorial to estimate a parameter method (Weibull) from a survival function for use in CEA models. Extrapolation to a lifetime horizon is possible using a series of methods based on parametric survival models (e.g., Weibull, exponential) but performing these projections can be challenging without the appropriate data and software. However, these Kaplan-Meier curves may only provide survival data up to a few months to a few years. Data for mortality are normally derived from survival curves or Kaplan-Meier curves published in clinical trials. In cost-effectiveness analysis (CEA), a life-time horizon is commonly used to simulate a chronic disease.
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The Portuguese Podengo is an ancient breed that is believed to have derived from the hounds brought into the Iberian Peninsula by Phoenician traders from Asia Minor. The Portuguese Podengo Pequeno is an ancient, no-nonsense hunting hound from Portugal. They are also extremely faithful to their owners and make excellent companions. As it’s a highly intelligent breed with an agreeable personality, they are often easy to train. Pequenos, like all Podengos, are hardy, active and extremely intelligent. The tail tapers off into a point and is curved like sickle. The dog’s back is fairly elongated and muscular. The smallest of the three Podengos, the Pequeno has a distinctive wedge-shaped head, pointy erect ears and expressive almond-shaped head. Podengos also comes in two coat variants – wiry haired and soft haired. These three sizes are generally not cross-bred and each has their own purpose. They are multi-sensory hounds that hunt using both their sight and scent and come in three distinct sizes: The smallest Pequeno, the medium sized Médio and the large Grande. Though largely predictable (Pop is on the toilet, Craig is lighting up a joint, the cops are idiots) the mildly funny moments in the film succeed for the most part. Yep, it must be another Friday in the ‘hood! Without Chris Tucker and Tiny Lister around to reprise their original and pivotal humorous roles, first-time director Marcus Raboy relies on a comely crew of comedic talents to bring on the laughs, namely Mike Epps’s slow-on-the-uptake Day-Day, John Witherspoon’s intestinally-challenged Pop and new addition Katt Micah Williams in a scene-stealing/star-making turn as the diminutive Prince-like wannabe pimp Money Mike. police smoke up your marijuana plant and have your Christmas party turn into a rent party. The family fortune is gone and everybody’s working at the mall back in the ghetto-the only place, Craig says, “where you can get robbed by Santa Claus on Christmas Eve.” Not only robbed, it seems, but also where you can get a beat-down with your own Christmas tree, have hapless L.A. When last we left Craig, he had moved on up to Beverly Hills to share in his family’s newfound wealth (translation: they done won the lottery). The dead fly was purchased by production.“Twas the night before Christmas and all through the house, not a creature was stirring…except for a skinny, drunk-ass, rundown Ghetto Santa boostin’ everybody’s holiday stash!” So begins yet another Friday for Ice Cube’s no-luck Craig Jones and his all-too-familiar gaggle of ‘hood rat caricatures, made infamous in the first two installments of this curiously popular franchise. A trainer released the flies into the room and none were harmed for filming. Other patrons swat their necks as flies buzz around. In another scene, inside the Holy Moly Donut shop, a man smashes a fly on the window and then picks it up and flicks it to the ground. For the bite, a trainer doubled as the actress wore the pooch's favorite squeaky toy taped to his padded pants, which the dog eagerly chomped. A plastic tube was placed under the covers to guide the dog in the proper direction. The dog was then cued to run to the bedroom and jump up on the bed. To achieve this action, the trainer cued the dog with verbal and hand signals to run to the mail slot, grab the papers, and tear them up. The landlady sneaks into the bedroom and the dog peeks out from under the covers and bites her rear end. The dog rips up the letters and then guiltily hides under the covers in the bedroom. Later, Cheeco excitedly runs to the front door and grabs mail from the slot. The trainer placed the dog on the bed next to the actor and cued the animal from off-camera using verbal and hand signals. The actor and dogs were introduced to each other during rehearsals and quickly became off-screen buddies. When Craig tries to wake up Day Day, the dog sits up in bed and nestles by his owner's head. In one scene, Cheeco sleeps on his back next to Day Day. Two English bulldogs named Echo and Buddy shared the role of Day Day's dog, Cheeco. Release Date: Friday, November 22, 2002.Starring: Ice Cube, Mike Epps and John Witherspoon.They also monitor conditions in which animals were housed during production. Safety Representatives reviewed the script and action scenes before and during filming to ensure that animals were not harmed or mistreated and that AHA Guidelines for the Safe Use of Animals in Filmed Media were upheld. The AHA has sole authority, through a contract between Producers and the Screen Actors Guild, to protect animals used in film and television. The Film and TV Unit of the American Humane Association (AHA) monitored the action sequences involving animals. One bright spot for the guys is Day Day's rambunctious canine Cheeco, featured in several comedic scenes. Just when things are looking up, they realize that a Santa-suited burglar has stolen their rent money, forcing them to take jobs as mall security guards to earn it back before their landlady gives them the boot. In this third installment of the Friday film series, cousins Craig (Ice Cube) and Day Day (Mike Epps) have finally moved out of their parents' homes and into their own place. |